TECHNOLOGICAL VISION



1. Development of hand-held and robotic assisted colon intubation system for screening colonoscopy and in-hospital

assisted colon preparation for screening colonoscopy


2. Development of a specialty endoscope (vision and irrigation/suction functions only) for assisted colon preparation

for screening colonoscopy adapted for use with the robotic assisted colon intubation system in partnership with a GI

endoscope manufacturer


3. Development of a low cost, disposable and reusable, colonoscopes for screening (vision function and water jet only)

or therapy (vision function and instrument channel only) adapted for use with the robotic assisted colon intubation

system in partnership with a GI endoscope manufacturer


4. Development of a specialty colonoscope with a robotic assisted angulation control adapted for use with the robotic

assisted colon intubation system in partnership with a GI endoscope manufacturer for precision polypectomy and ESD

with conventional tools, e.g., snares and forceps.


5. Development of robotic assisted endoluminal (colon) surgery system based on the robotic assisted colon intubation

and stabilization system platform





CORE TECHNOLOGICAL BASIS OF IMPROVED COLON INTUBATION



1. The known technical difficulties of intubating the colon is eased by employing a Push-Pull intubation operation,

that is, an alternating actions of pushing the endoscope and pulling the colon over the endoscope to maintain a

smooth curvature in and prevent looping of the endoscope rather than by a Push operation alone, that is, forcefully

pushing the endoscope through the tortuous colon anatomy.


2. The Push-Pull intubation action, either done manually or with robotic assistance, is enabled by an overtube

designed to selectively engage to manipulate and disengage the colon.





COLLABORATION PROPOSED (GUIDELINE)



1. Aim



- Tap into the population CRC screening colonoscopy market (>35 million procedures/year even at suboptimal

population compliance) by providing new technological solutions for the persistent and intractable problems of colon

intubation enabling: (1) efficient and less painful (reduced sedation) procedure and (2) onsite assisted colon

preparation (mild pre-visit colon preparation requirements for patient).



- Establish a new technological foundation for revolutionizing the lower and upper GI endoscopy markets

spanning diagnosis and therapeutic intervention for the GI abnormalities with conventional manual tools, e.g., snares

and forceps, and robotically controlled surgical tools adapted for use with GI endoscopes, e.g., articulating

instruments with multiple degrees of freedom.




2. A "Build-to-Buy" Model: Joint effort with technical/financial contributions from collaboration partners




- Endoscape Colonoscopy:


-- Architecture and device designs for hand-held and robotic assisted colon intubation subsystems

-- Architectural designs of specialty GI endoscope instruments and accessory/adjunct instruments




- Prospective Partner(s):


-- A manufacturer of currently marketed GI endoscopy products: Specialty GI endoscope instruments and

accessory/adjunct instruments for hand-held and robotic assisted GI endoscopy


-- A manufacturer of robotic assisted surgery system: Robotic assisted GI endoscopy system hardware and opearting

system software, and associated endoluminal surgical instruments




- Financial Partner(s)




- Exit through sale of Endoscape Colonoscopy as a whole or in parts (hand-held and robotic assisted) to a

collaboration partner(s)






HEADQUARTER: SANTA CLARA, CA, USA